2016 Fiscal Year Final Research Report
Role of chondrocyte DNA repair enzymes in the degeneration of articular cartilage in osteoarthritis.
| Project/Area Number |
26462323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
YUDO KAZUO 聖マリアンナ医科大学, 医学研究科, 教授 (60272928)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 変形性関節症 / 軟骨細胞 / 核酸修復酵素 |
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| Outline of Final Research Achievements |
Aging is one of the major pathologic factors associated with osteoarthritis (OA). It has been indicated that the NAD-dependent deacetylase sirtuin-1 (Sirt-1) has an important role in human aging.It has been suggested that Sirt-1 promotes osteogenic and chondrogenic differentiation of mesenchymal stem cells.
We postulated that Sirt-1 regulates a hypertrophic chondrocyte lineage and osteophyte formation through the activation of osteogenic transcription factor Runx2 in osteoarthritic chondrocytes.Our findings suggest that the NAD-dependent deacetylase Sirt-1 may upregulate the osteophyte formation and the expression of cartilage degrading enzyme MMP-13 through the mechanism involving the acceleration of the osteogenic transcription factor Runx2 in OA cartilage tissues.
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| Free Research Field |
整形外科
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