Effects of anesthetic-induced precoditioning on cardiac ion channels

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Asahikawa Medical College
• Principal Investigator: TAMPO Akihito 旭川医科大学, 医学部, 講師 (80531524)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: プレコンディショニング / 心筋傷害 / 麻酔プレコンディショニング / 虚血・再灌流傷害

Outline of Final Research Achievements

In this study, we evaluated the APC effects on sodium channel in the Dahl-S rats which were not pre-conditioned by anesthetics. Increase in the sodium current, and channel protein expression by APC was abolished in the Dahl-S rats. Five minutes oxidative stress and reperfusion injury increased the sodium current in 10 and 15 minutes reperfusion, but the change was not observed in the anesthetic-preconditioned cardiomyocytes. These results suggested that APC treatment reduced myocytes injury by sodium overload and following calcium overload. The increased sodium current by APC was decreased by 30 minutes ischemia-reperfusion injury.

Free Research Field

麻酔，集中治療