2017 Fiscal Year Final Research Report
Effects of anesthetic-induced precoditioning on cardiac ion channels
Project/Area Number |
26462326
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
TAMPO Akihito 旭川医科大学, 医学部, 講師 (80531524)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Keywords | プレコンディショニング / 心筋傷害 / 麻酔プレコンディショニング / 虚血・再灌流傷害 |
Outline of Final Research Achievements |
In this study, we evaluated the APC effects on sodium channel in the Dahl-S rats which were not pre-conditioned by anesthetics. Increase in the sodium current, and channel protein expression by APC was abolished in the Dahl-S rats. Five minutes oxidative stress and reperfusion injury increased the sodium current in 10 and 15 minutes reperfusion, but the change was not observed in the anesthetic-preconditioned cardiomyocytes. These results suggested that APC treatment reduced myocytes injury by sodium overload and following calcium overload. The increased sodium current by APC was decreased by 30 minutes ischemia-reperfusion injury.
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Free Research Field |
麻酔,集中治療
|