Effects and neuroprotection of the anesthetic agent in the spinal ventral horn neuron

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Niigata University
• Principal Investigator: HONDA Hiroyuki 新潟大学, 医歯学総合病院, 講師 (20535174)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 麻酔薬 / 脊髄前角ニューロン / 神経保護

Outline of Final Research Achievements

The elucidation of the immobilization mechanisms of the anesthetic agent in the spinal cord is important. However, the mechanisms in the ventral horn neurons is not clear. Furthermore, the protection mechanisms of the anesthetic agent for spinal cord ischemia is unknown. Therefore, in this study, we analyzed the mechanisms of the anesthetic agent in the ventral horn neurons. Nitrous oxide inhibited the glutamatergic excitatory postsynaptic currents in the ventral horn neurons. In contrast, the volatile anesthetics increased the gamma-aminobutyric acid mediated inhibitory postsynaptic currents. Furthermore, both of nitrous oxide and the volatile anesthetics extended the time before leading to cell death during the spinal cord ischemia. Thereby, we found that these anesthetic agents had ischemia-resistant effects in ventral horn neurons.

Free Research Field

麻酔科学