neuroprotection by the maintenance of blood brain barrier

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462334
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Gifu University
• Principal Investigator: Tanabe Kumiko 岐阜大学, 大学院医学系研究科, 准教授 (30402209)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 中枢神経保護 / サイトカイン / 細胞内情報伝達

Outline of Final Research Achievements

It has been reported that interleukin (IL)-1β induces IL-6 synthesis in rat glioma cell line, C6 cells and that cAMP enhances IL-1β-induced IL-6 synthesis. We investigated the details behind enhancement of IL-1β-induced IL-6synthesis by cAMP.
In conclusion, adenylyl cyclase/cAMP/PKA pathway upregulates IL-1β-induced IL-6 synthesis through enhancement of the JAK2/STAT3 pathway. In addition, dexmedetomidine, intravenous anesthetic agent, inhibits IL-1β-induced IL-6 synthesis independently of the adenylyl cyclase/cAMP pathway through its receptor (α2 adrenoceptor).

Free Research Field

麻酔学・疼痛治療