Elucidation of the mechanism of central nervous system disorder caused by severe infections focused on water channel and development of novel therapeutic methods.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462343
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Nagoya City University
• Principal Investigator: So MinHye 名古屋市立大学, 大学院医学研究科, 助教 (60381886)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 水チャネル / 高次脳機能 / 敗血症 / 炎症

Outline of Final Research Achievements

We aimed to elucidate the pathogenesis of higher brain dysfunction accompanying severe infection and establish a new treatment strategy.
The expression of aquaporin 9 (AQP 9), a water channel, was confirmed to be decreased by administration of inflammatory cytokine or endotoxin to cultured cells. In addition, we confirmed elevation of inflammatory cytokine and decreased expression of AQP9 in the brain of sepsis model mouse, and the decrease of AQP 9 could be suppressed by administration of dexamethasone. Next, behavioral experiments of sepsis model mice confirmed higher brain dysfunction, and an improvement trend was confirmed by administration of dexamethasone. Furthermore, endotoxin was administered to cultured astrocytes, cDNA microarray was performed, and many factors whose expression fluctuated were confirmed, so we will narrow down.

Free Research Field

麻酔科学