2016 Fiscal Year Final Research Report
Elucidation of pathogenesis for septic encephalopathy based oh new mitochondrial endoplasmic reticulum control pathway
| Project/Area Number |
26462348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シノビオリン / 敗血症性脳症 / メタボローム / ユビキチンリガーゼ / KAT |
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| Outline of Final Research Achievements |
In this study, we focus on cerebral synoviolin (Syvn) as a ubiquitin ligase (E3) involved in endoplasmic reticulum-related degradation mechanism, the mechanism of septic encephalopathy (SE) was investigated. As a result,1 Metabolome analysis of intracerebral metabolic pathway via Syvn showed a marked decrease in kynurenic acid and a significant increase in kynurenine at 18 hours after SE onset. It became clear that kynurenine plays an important role in inducing the impaiment of the brain. 2 KAT activity by SE was increased, especially, activity of KAT4 significantly increased 18 hours after CLP model creation. Conclusion: Suppression of Syvn and reduction of kinurenine suppresses neuropathy and it may lead to improvement of septic encephalopathy.
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| Free Research Field |
麻酔・蘇生学
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