Effect of xenon on GABA and glutamatergic synaptic responses

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462349
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Kumamoto Health Science University
• Principal Investigator: Nonaka Kiku 熊本保健科学大学, 保健科学部, 准教授 (70259745)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: シナプス / キセノン / GABA / グルタミン酸

Outline of Final Research Achievements

To clarify how a gaseous anesthetic xenon (Xe) modulates the excitatory and inhibitory synaptic transmission, present electrophysiological study was performed in namely “synapse bouton” preparation of rat hippocampal CA3 neurons dissociated mechanically. The preparation allows the detail analysis of Xe action at single and multy synapse levels. Xe inhibits both pre- and postsynaptic sites in glutamatergic transmission while Xe inhibits only presynaptic site in GABAergic transmission, though the predominant action of Xe on glutamatergic transmission is due to presynaptic site. The present result is absolutely a new finding that does not agree with all reports in which Xe acted only the postsynaptic site in both the excitatory and inhibitory system.

Free Research Field

神経生理