Is angiogenesis in regenerative medicine influenced by vascular preconditioning?

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: KAWAHITO Shinji 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (60284296)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 再生医療 / 血管新生 / 周術期管理法 / 血管プレコンディショニング

Outline of Final Research Achievements

We examined the influence of vascular preconditioning (hypoxic and remote preconditioning) on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of vascular preconditioning should be less. Basic experiments using cultured cells indicated endothelial cell migration was significantly stimulated with FBS (2% fetal bovine serum), however, vascular preconditioning did not show any significant enhancing or suppression effects on endothelial cell migration. It is hoped that a new indicator of the perioperative administration in established by the influence of vascular preconditioning which gives it to angiogenesis being elucidated.

Free Research Field

医歯薬学