2016 Fiscal Year Final Research Report
A basic research to elucidate the mechanism of preconditioning against ischemia-reperfusion injury and its therapy
| Project/Area Number |
26462368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | International University of Health and Welfare (2016)
Yokohama City University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Izumu 東京大学, 医科学研究所, 教授 (70158913)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ARDS / 再灌流傷害 / HIF / 低酸素 / アポトーシス |
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| Outline of Final Research Achievements |
Ischemia occurs in accordance with hypoxia. It is well known that hypoxia-inducible factor (HIF)-1 expresses in hypoxic tissue and has an anti-inflammatory property. Acute respiratory distress syndrome (ARDS), a major cause of hypoxia, causes apoptosis through Fas/FasL pathway. Dimethyloxalylglycine (DMOG), a prolyl hydroxylase domain protein (PHD) inhibitor, suppresses Fas and thus diminishes apoptosis, which preserves the alveolar barrier function. Anti-apoptotic effects of DMOG and the suppression of Fas effects were not observed when HIF-1 pathway was inhibited by some ways such as siRNA. These findings suggest that anti-apoptotic effects of DMOG are dependent of HIF-1.
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| Free Research Field |
肺傷害
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