Development of ventilator-associated lung injury prevention method focused on antioxidant action.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462369
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Nagoya City University
• Principal Investigator: HIRATE Hiroyuki 名古屋市立大学, 大学院医学研究科, 助教 (20363939)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 人工呼吸器関連肺障害 / 肺保護 / 抗酸化物質

Outline of Final Research Achievements

Ventilator-related lung injury (VILI) is a problem, but effective prophylaxis has not been established, so this study investigated the VILI model of the mouse as a function of ventilation frequency, ventilation rate, ventilation time, end-tidal expiration. This model was used to establish drugs and nutrients useful for pulmonary protective ventilation conditions and VILI alleviation.
After administering antioxidant substances, artificial respiration was performed to examine the reduction of VILI, but it was not possible to identify effective substance. Artificial respiration was also given to mice to which containing antioxidant was administered in advance, but no reduction effect of VILI was observed. We tried artificial respiration to AKITA mouse which is a model mouse of diabetes, but it was difficult to control breathing condition and blood glucose level, and it was difficult to study.

Free Research Field

集中治療医学