2016 Fiscal Year Final Research Report
New strategy to save the blood transfusion using antithrombin and fibrinogen
| Project/Area Number |
26462374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 輸血 / 血液凝固 / ポイントオブケア |
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| Outline of Final Research Achievements |
The investigation aimed to the efficacy of hemostatic therapy guided either by conventional coagulation analyses proposed by Ministry of Health,Labour and Welfare (Control) or point of care (POC), such as Thromboelastometry (ROTEM) and Hepcon HMS testing in cardiac surgery patients. Sixty patients were enrolled in the study. After randomization of the patients to each group, there was no significant difference in red blood cells (RBCs), fresh frozen plasma (FFP), and platelet concentrate (PC) transfusion in the Control group compared with the POC group peri-operatively. The secondary outcome parameters of blood loss during operation and the first 48 h after ICU were not significant between the Control and the POC group, either. Hemostatic therapy based on POC testing could not reduce patient exposure to allogenic blood products.
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| Free Research Field |
麻酔科学
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