Mechanisms of persistent postoperative pain after laparotomy and analgesic treatments

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462380
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Shinshu University
• Principal Investigator: TANAKA Satoshi 信州大学, 学術研究院医学系, 准教授 (60293510)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 局所麻酔薬 / 術後痛

Outline of Final Research Achievements

The purpose of this study was to investigate the underlying mechanisms of severe pain after open abdominal surgery using our new animal model with laparotomy and appendectomy. Skin incision induced mechanical hyperalgesia in the surgical site but did not affect spontaneous locomotor activity. Laparotomy induced mechanical hyperalgesia not only in the surgical site but also in the site distant from the surgical site and reduced locomotor activity. The number of c-Fos-positive neurons in the thoracic dorsal horn in the laparotomy group was higher than that in the skin incision group, which were reduced by administration of a local anesthetic into the surgical site. Although there were no significant differences in the pain-related behaviors between the laparotomy and appendectomy groups, recovery from postoperative weight loss in the appendectomy group delayed. Spontaneous locomotor activity and area of mechanical hyperalgesia vary according to degree of the surgical stress.

Free Research Field

麻酔科学