2016 Fiscal Year Final Research Report
The role of TRPA1 in postoperative pain and wound healing
| Project/Area Number |
26462383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Hasegawa Maiko 鹿児島大学, 医歯学域医学系, 准教授 (20516637)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | TRPA1 / 術後痛 / 創傷治癒 / 急性炎症 |
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| Outline of Final Research Achievements |
The correlation between inflammation and acute postoperative pain was investigated using TRPA1-/- mice. In TRPA1-/- mice, mechanical threshold was not altered at the sites of incision. However, the number of neutrophils and M1 macrophages was significantly decreased on POD2. Similarly, M2 macrophages was decreased on POD7, whereas the production of TNF-α and COX-2 was increased. In late phase of postoperative period, pain intensity may not be consistent with the production of pro-inflammatory mediators.
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| Free Research Field |
麻酔科学
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