2016 Fiscal Year Final Research Report
Application of tumor endothelial derived exosomal-miRNA for cancer diagnosis and therapy.
| Project/Area Number |
26462388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 腎癌 / miRNA |
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| Outline of Final Research Achievements |
In this study, we have tried to identify tumor endothelial miRNAs which are exported by tumor exosome and induce cancer invasion and metastasis. Normal and tumor endothelial cells were isolated from human normal renal tissue and renal tumor tissue respectively. miRNAs were isolated from each endothelial cells and compared to each other by miRNA array. miRNA target genes were identified using public data base. Among miRNA which were picked up, we identified miRNA that induce cancer invasion and metastasis. These results suggested that tumor blood vessel affect cancer cell phenotype via miRNAs.
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| Free Research Field |
泌尿器科学
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