2016 Fiscal Year Final Research Report
Development of an antineoplastic virus utilizing a tumor-specific promoter effective against multiple urologic tumors
| Project/Area Number |
26462401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Takeshima Yuta 東京大学, 医学部附属病院, 登録診療員 (10372393)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 遺伝子治療 / ウイルス療法 / ヘルペスウイルスＩ型 / 泌尿器がん |
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| Outline of Final Research Achievements |
The triple-deleted oncolytic herpes simplex virus type I G47delta represents the cutting edge of a new field of oncotherapy utilizing genetically-engineered viruses. Of the three deletions, the deletion of the ICP6 gene may in theory make viral replication reliant on host enzyme level, and thus be inhibited in slower-growing tumors. Using the G47delta as the backbone, we created a new oncolytic HSV-1 with an intact ICP6 gene under the control of tumor-specific promoters to eliminate this effect, and enhance viral growth and efficacy against slower-growing tumors. We hope this new virus will further stimulate the use of viral agents in oncotherapy.
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| Free Research Field |
泌尿器科学
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