2016 Fiscal Year Final Research Report
The functional analysis of FABP7, the examination of the triglyceride metabolism and the research to the prevention of renal cell carcinoma
| Project/Area Number |
26462407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | FABP7 / ドコサテトラエン酸 / EPA / GPD1 / GPD2 |
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| Outline of Final Research Achievements |
Expression of brain-type fatty acid-binding protein (FABP7) is specifically on renal cell carcinoma (RCC). FABP7 would be worked to stimulation or repression of cell proliferation according to the influence of other factors. It suggests the complicated outbreak mechanism of cancer became clear. In addition, FABP7 has a possibility to be applicable for a treatment target of RCC, because a neoplasia promotion effect was seen by the expression of FABP7. Further, the glycerol-3-phosphate dehydrogenase 1 (GPD1) is on the metabolic pathway that links the triglyceride synthetic pathway to the glycolytic pathway. Expression of GPD1 was weaker in RCC than a kidney tissue. It suggests that GPD1 may be available for the treatment of RCC.
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| Free Research Field |
泌尿器科癌
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