2016 Fiscal Year Final Research Report
Molecular mechanisms of ligand-independent androgen receptor activation in development and progression of prostate cancer
| Project/Area Number |
26462408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Mie University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 前立腺癌 / 癌関連線維芽細胞 / アンドロゲン受容体 / 前立腺特異抗原 / 前立腺癌間質標的療法 |
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| Outline of Final Research Achievements |
Tumor stroma surrounding prostate cancer (PCa) cells is enriched in fibroblasts secreting androgen receptor (AR)-activating factors. Thus, fibroblast-dependent AR activation in PCa cells under androgen deprivation therapy (ADT) may play an important role in progression of castration-resistant prostate cancer (CRPC). In this study, we investigated the role of fibroblasts in AR activation of PCa cells differing in androgen sensitivity. In the condition of co-cultures with fibroblasts, PSA production was directly increased in E9 cells but not in F10 and AIDL cells. In E9 cells + pcPrF-M5 group, tumor growth became diminished post ADT but serum PSA was gradually increased even post ADT. Here our results have demonstrated that fibroblast-dependent AR activation under ADT showed diverse effects in PCa cells differing in androgen sensitivity. In a certain androgen-low-sensitive PCa cells, fibroblast-dependent AR activation may progress to CRPC.
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| Free Research Field |
泌尿器科学
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