2016 Fiscal Year Final Research Report
Molecular mechanism of epithelial-mesenchymal transition in castration resistant prostate cancer.
| Project/Area Number |
26462412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 前立腺癌 / 去勢抵抗性前立腺癌 / 上皮間葉移行 |
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| Outline of Final Research Achievements |
The Objective of this study was to investigate the significance of epithelial-mesenchymal transition in castration resistant prostate cancer. A study of immunohistochemical staining using clinical tissue samples revealed that N-cadherin was overexpressed in prostate cancer. N-cadherin overexpressed cells showed aggressive features in vitro. N-cadherin overexpressed cells acquired resistance against docetaxel. The acquired resistance was reversed by in vitro treatment using antisense oligonucleaotide against clusterin, one of the stress-induced protein related with anti-apoptotic cell survival in many kinds of cancer cells.
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| Free Research Field |
前立腺癌
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