2016 Fiscal Year Final Research Report
Study for elucidating tumor suppressive microRNA that has anti proliferation and prevent metastasis by using metastasis model mouse in bladder cancer
| Project/Area Number |
26462416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATAOKA Kazunori 東京大学, 疾患生命工学センター, 教授 (00130245)
MIYATA Kanjiro 東京大学, 疾患生命工学センター, 准教授 (50436523)
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| Research Collaborator |
INOGUCHI Satoru 鹿児島大学, 医歯学総合研究科, 大学院生
ISHIHARA Tomoaki 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マイクロRNA / 膀胱癌 |
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| Outline of Final Research Achievements |
Based on the microRNAs expression profile by next generation sequencing in bladder cancer, we identified several tumor suppressive microRNAs including miR-144-5p/3p and miR-23b/24/27b and found their target tumor-associated genes such as c-MET, EGFR involved in important cancer signaling pathway or cyclin E1/E2 involved in cell cycle. MicroRNA-based studies revealed novel cancer biology. We are planning in vivo study following these results.
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| Free Research Field |
泌尿器癌
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