Elucidation of characteristic alterations of spermatogonial stem cells in testicular cancer and application to genome-based drug discovery using novel cell line

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: MIZUNO Kentaro 名古屋市立大学, 大学院医学研究科, 講師 (70448710)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 精子幹細胞 / 精巣がん / 細胞分化

Outline of Final Research Achievements

Spermatogonial stem cells (SSCs), which is the stem cells of testicular tissue, undergo self-renewal with preserving pluripotency and act as the source of spermatozoa after puberty throughout life. Recently, it is suggested that phenotypic alteration of SSCs is involved in the onset of testicular cancer. We investigated the phenotypic alteration of SSCs using animal model of cryptorchidism, which is one of the etiology of testicular cancer. Subsequently, we elucidated that the expressions of histone modifying enzyme Kdm5a and microRNA miR-135a were significantly changed in the cryptorchid testes, via androgen action.

Free Research Field

泌尿器科学