2016 Fiscal Year Final Research Report
Analysis of functional RNA networks and investigation of their target genes in castration-resistant prostate cancer (CRPC).
| Project/Area Number |
26462430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 前立腺癌 / マイクロRNA / 発現プロファイル / 去勢抵抗性 / 遺伝子解析 / 癌抑制遺伝子 |
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| Outline of Final Research Achievements |
The expression levels of miR-452 was decreased in castration-resistant prostate cancer (CRPC), and the transfection of miR-452 induced repression of cell migration and invasion in PC3 and Du145 cells. One of the target genes is E3 ubiquitin ligase-1 (WWP1). Knock-down of expression levels of WWP1 induced repression of cell migration and invasion in PC3 and Du145 cells, indicated WWP1 is an oncogene. CRPC patients with lower levels of miR-452 showed short duration of time to CRPC after androgen depletion therapy. miR-452 is a prognostic factor of progressed prostate cancer and targeting WWP1 expression might be a possible treatment for CRPC.
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| Free Research Field |
前立腺癌
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