Analysis of urethral function through hydrodynamic computation of urine flow focused on focal therapy for voiding dysfunction.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Chiba University
• Principal Investigator: Igarashi Tatsuo 千葉大学, フロンティア医工学センター, 教授 (70302544)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 排尿障害 / 流体計算 / 尿道ファントーム / 仮想内視鏡 / 立体画像再構築 / 管腔臓器 / 下部尿路

Outline of Final Research Achievements

We continued to develop diagnostic system to identify urethral lesions of the prostatic urethra responsible for voiding dysfunction. The purpose of the research is to offer endoscopic “focal therapy” for male patients with voiding dysfunction. After computing flow dynamics of intraluminal urine flow using solid model, we prepared phantom models of the prostatic urethra with or without bladder outlet obstruction surrounded by a material mimicking prostatic elasticity. Cross sectional plane of the phantom was monitored by ultrasonography. The data of the urethral motion was captured in a virtual urethral model, and coupled analysis was performed. When compared pressure distribution between normal and obstructed model at peak urine flow stage, prominent difference was observed at the bladder, bladder outlet and the sphincter level. The data corresponded with clinical findings, and would validate to detect the lesion responsible for voiding dysfunction.

Free Research Field

医工学、排尿機能、低侵襲手術