A preliminary study of neuronal plasticity on neuromodulation in rats

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of Fukui
• Principal Investigator: MATSUTA Yosuke 福井大学, 学術研究院医学系部門(附属病院部), 講師 (90345687)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Neuromodulation / 脛骨神経 / 神経可塑性 / 神経伝達物質 / 過活動膀胱

Outline of Final Research Achievements

Female Sprague-Dawley rats were used in this study. The effect of unilateral electrical stimulation (ES) on neurogenic storage dysfunction model was investigated. We used two models of neurogenic storage dysfunction. Cerebral infarction (CI) model was made by an unilateral embolization of middle cerebral artery, and spinal cord injury (SCI) model was made by a transection of spinal cord at the level of T 7/8. Stimulation was set as 5 Hz and 200 μsec bipolar pulse wave according to the previous study. Peripheral somatic nerve was stimulated via a cuff electrode implanted around the left tibial nerve. Cystometric study revealed no significant changes in spite of the initiation of ES. Therefore, we did not investigate neurotransmitters and gene expression concerning neuronal plasticity.

Free Research Field

医歯薬学