Study on effects of bushi for opioid receptor Kappa type of bladder pain model

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462439
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of Yamanashi
• Principal Investigator: TSUCHIDA Takayuki 山梨大学, 総合研究部, 医学研究員 (30217327)
• Co-Investigator(Renkei-kenkyūsha): MIYAMOTO Tatsuya 山梨大学, 総合研究部, 助教 (80456459) ; KOBAYASHI Hideki 山梨大学, 総合研究部, 講師 (50402053) ; ZAKOUJI Hidenori 山梨大学, 総合研究部, 准教授 (60345717) ; TAKEDA Masayuki 山梨大学, 総合研究部, 教授 (80197318)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ブシ / ナルフラフィン塩酸塩 / κオピオイド

Outline of Final Research Achievements

o determine the effect using the κ-opioid receptor antagonist medication norvinaltorphimine is administered in the treatment group compared to. Also considering the comparison with nalfurafine hydrochloride administered as a κ-receptor-selective cholinergic drug group. Capacity of the "Bush" effect was verified in experiments for nalfurafine hydrochloride, consider "bushy," examined various capacities, but did not statistically significant results. Sliding plate "busy" system and the nalfurafine system which is difficult. May we at least use "busy" and nalfurafine hydrochloride than single use further affect the opioid receptor-type and expected future development.

Free Research Field

医歯薬学