2016 Fiscal Year Final Research Report
the functional and morfological evaluation of extracellular matrix in urethral tissue
| Project/Area Number |
26462446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Oita University |
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Principal Investigator |
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| Research Collaborator |
Shinohara Mayuka
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | コラーゲンⅩⅨ / Leak point pressure / 外尿道括約筋 / 尿禁制 |
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| Outline of Final Research Achievements |
We explored whether CollagenⅩⅨ, one of FACIT collagens, effects on the rhabdosphincter. We made CollageⅩⅨ knockout female mice and used 129/wild type female mice as control. We measured Leak Point Pressure as the functional assessment, and mean area of urethral lumen and urethal circumference of as morphological evaluations at 4week-old.
In resuls, there were no significant difference between two groups in functional and morphogical enaluations. So, CollagenⅩⅨ doesn’t involve with function of rhabdosphincter.
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| Free Research Field |
排尿機能
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