Basic research to realize personalized medicine based on pharmacogenomics and drug discovery in benign prostatic hyperplasia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Fukushima Medical University
• Principal Investigator: Kojima Yoshiyuki 福島県立医科大学, 医学部, 教授 (60305539)
• Research Collaborator: KATAOKA Masao 福島県立医科大学, 医学部 泌尿器科学講座, 学内講師 (90554204) ; OGAWA Soichiro 福島県立医科大学, 医学部 泌尿器科学講座, 学内講師 (50554200) ; AKAIHATA Hidenori 福島県立医科大学, 医学部 泌尿器科学講座, 助教 (70644178) ; SATO Yuichi 福島県立医科大学, 医学部 泌尿器科学講座, 助手 (00706848) ; YABE Michihiro 福島県立医科大学, 医学部 泌尿器科学講座, 博士研究員 (30745782) ; HATA Junya 福島県立医科大学, 医学部 泌尿器科学講座, 助教 (00769606)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 前立腺肥大症 / 細胞増殖 / 一塩基遺伝子多型 / オーダーメード医療 / ゲノム薬理学 / 筋線維芽細胞 / サイトカイン / 増殖因子

Outline of Final Research Achievements

Recently, a rat model of BPH produced by implanting fetal urogenital sinus (UGS) into adult rat ventral prostate was developed. Using this model, we found that genes associated with growth factors, cytokines and chemokines were up-regulated in the BPH specimens compared with those in normal prostate, suggesting that their multiple families act through paracrine signaling to stimulate prostate proliferation. In addition, we found that myofibroblasts differntiation played a significant role in prostate growth in BPH.
Genome-wide association studies can link multiple SNPs to drug response. More limited genetic variant studies have been performed within alpha1-AR subtypes SNPs within a biologic pathway implicated in BPH could improve predictive ability. We have found 9 potential candidate SNPs associated with the efficacy of alpha1-AR antagonists, although further study will be needed.

Free Research Field

泌尿器科