2016 Fiscal Year Final Research Report
Establishment of diagnostic markers for recuccent stone disease by genome-wide associated analysis.
| Project/Area Number |
26462450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 尿路結石 / ゲノムワイド関連解析 / マルチプレックス解析 / 炎症 / マクロファージ / リスク因子 |
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| Outline of Final Research Achievements |
We have conducted large-scale screening focusing on single nucleotide polymorphisms (SNPs), identified multiple urinary calculi related regions on the genome, and reported the association with onset risk. In this study, we performed (1) haplotype analysis of the related genes based on the results of genome-wide association analysis, and (2) multiplex analysis for kidney stone-related urinary markers between kidney stones and healthy subjects.
As a result, we identified 5q 35.3, 7 p 14. 3 and 13 q 14. 1 areas related to stone formation and found that the odds ratio increased with the number of risk allele . In addition, urinary IL-1a and IL-4 were identified as the factors to discriminate normal subjects from calculus patients (especially initial stone formers) by multiplex analysis of urinary inflammation-related factors.
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| Free Research Field |
尿路結石
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