The role of TSP-1 in the pathogenesis of benign prostatic hyperplasia via inflammation.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462451
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 研究員 (50225869)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 前立腺肥大症 / TSP-1 / 炎症

Outline of Final Research Achievements

Previously, we reported that interleukin-18 (IL-18) may promote stromal hyperplasia in the prostate by inducing production of thrombospondin-1 (TSP-1) using BPH rat model.
First, To clarify the role of TSP-1 in the development of BPH, we administered the IL-18-binding protein (IL-18BP), an inhibitor of IL-18, in the peritoneum of the model rats. The administration of IL-18BP affected the dose-dependent decreases in TSP-1 mRNA expression levels. The Masson trichrome stain of rat prostate showed that the expression levels of the collagen fibrils were likely decreased by the administration of IL-18BP in the BPH tissues. Next study, we aimed to determine the expression levels of TSP-1 in human prostate tissue and assess the correlation of these expressions and clinical parameters. As a result, TSP-1 was positively correlated with prostate volume and the increase in prostate volume per day.

Free Research Field

排尿障害