2017 Fiscal Year Final Research Report
Study of antimicrobial therapy for Mycoplasma genitalium urethritis
| Project/Area Number |
26462456
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
松本 哲朗 産業医科大学, 医学部, 名誉教授 (50150420)
|
|---|
| Research Collaborator |
JENSEN Jorgen Skov
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | Mycoplasma genitalium / 尿道炎 / sitaloxacin 耐性 / moxifloxacin 耐性 / マクロライド耐性 / 分離培養 |
|---|
| Outline of Final Research Achievements |
M. genitalium （MG）is one of pathogen for male urethritis. Recently, treatment-failure cases of M. genitalium urethritis are increasing. We studied the relationship between antimicrobial resitance and genetic mutations of MG. However, the isolation and culturing of MG have still difficult and we isolated first MG strain with multi-drug resistance was isolated in Japan. Almost 40 % MG strains in Japan are macrolide-resistance. Against these macrolide-resistant strains, moxifloxacin(MFLX) or sitafloxacin(STFX) are effective. We indicated the possibility that the point mutation on parC gene in MG induces MFLX-resistance and additional mutation on gyrA gene induces STFX-resistance.
|
| Free Research Field |
性感染症
|
