2017 Fiscal Year Final Research Report
ADAMTS13, vWF and Immunological accommodation in renal injury after ABO-incompatible kidney transplantation
| Project/Area Number |
26462457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 由紀 新潟大学, 医歯学総合病院, 助教 (70422607)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | ABO血液型不適合腎移植 / 免疫学的順応 / 抗体関連型拒絶反応 / 血栓性微小血管障害 / ADAMTS13 / ｖWF / 免疫学的不応答性 / PECAM-1 |
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| Outline of Final Research Achievements |
It has been still unknown that the establishment and maintenance mechanism of immunological accommodation after ABO-incompatible kidney transplantation.
Even now, antibody mediated rejection(AMR) and/or thrombotic microangiopathy(TMA) sometimes occurs in several cases. We have focused on the graft factor in which kidney endothelium express the blood type carbohydrate antigen with specific anchor proteins such as PECAM-1, vWF,ADAMTS-13 that is quite different from RBCs, which play a critical role in prevention of AMR and/orTMA and induction of accommodation. On the other hand, we have also found the recipient factor in which the donor-blood type specific inhibition of antibody production. We have approved it both in vivo and in vitro study. B cells derived from the patients have revealed that the immunological unresponsiveness, so-called B cell anergy against donor blood type antigen, which might be the real feature of the accommodation after ABO-incompatible kidney transplantation,
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| Free Research Field |
泌尿器科学
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