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2016 Fiscal Year Final Research Report

The prevention against chronic antibody mediated rejection on graft endothelial

Research Project

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Project/Area Number 26462458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionAichi Medical University (2015-2016)
Nagoya University (2014)

Principal Investigator

Iwasaki Kenta  愛知医科大学, 医学部, 准教授 (10508881)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords移植免疫 / 免疫順応 / 腎移植 / シグナル伝達 / 細胞保護
Outline of Final Research Achievements

Donor-specific antibody (DSA), particularly against HLA class II, is a major cause of chronic antibody-mediated rejection (CAMR) after transplantation, although ABO-incompatible kidney transplantation has recently demonstrated favorable graft outcomes. The condition of no injury even in the presence of anti-donor antibody has been referred to as “accommodation”, which would be one of the key factors for successful long-term graft survival. The purpose of this study was to analyze the beneficial effect of anti-blood group A/B antibody ligation on endothelial cells against HLA-DR antibody-mediated, complement-dependent cytotoxicity (CDC). Pre-incubation with anti-blood group A/B antibody had resistance to HLA-DR antibody-mediated CDC. This finding was ascribed to decreased expression of HLA-DR by post-translational regulation and increased expression of CD55/59, which was related to ERK and mTOR pathway inhibition.

Free Research Field

移植免疫

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Published: 2018-03-22  

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