2016 Fiscal Year Final Research Report
The role of phagocytes in the pathogenesis of endometriosis
| Project/Area Number |
26462478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOGA KAORI 東京大学, 医学部附属病院, 准教授 (10396723)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 子宮内膜症 / マクロファージ / 樹状細胞 |
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| Outline of Final Research Achievements |
We found that the proportion of mannose receptor (MR) positive - myeloid DC type 1 was higher in endometriosis samples than in controls. The blocking of MR reduced phagocytosis of dESC by Mo-DC. Mo-DC cultured with dESC expressed higher levels of interleukin (IL)-1β and IL-6 than controls.
According to these findings, we suggested that oeritoneal DC in endometriosis tissue express high levels of MR, which promotes phagocytosis of dead endometrial cells, and thereby contributes to the etiology of endometriosis.
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| Free Research Field |
産婦人科学
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