Development of diagnostic procedure and novel treatment of amniotic fluid embolism based on the pathological histology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Tamura Naoaki 浜松医科大学, 医学部附属病院, 助教 (90402370)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 羊水塞栓症 / 子宮弛緩 / 後産期出血 / アナフィラクトイド反応 / 後産期急性子宮筋層炎 / C1インヒビター

Outline of Final Research Achievements

In the myometrium of amniotic fluid embolism presenting with treatment-resistant postpartum hemorrhage, the infiltration of neutrophil, macrophage and activated mast cells expressed the receptor for anaphylatoxin were characteristic finding. This could be histopathologically expressed as postpartum acute myometritis that causes tissue edema. C1 esterase inhibitor (C1INH), potentially inhibits anaphylactoid reaction and vascular permeability, exhibited the effect of uterine contraction. This result suggested C1INH can be one of therapeutic products for amniotic fluid embolism with refractory uterin atony.

Free Research Field

産婦人科学