2016 Fiscal Year Final Research Report
The new therapeutic approach for reduction of severe complication in preterm neonates
Project/Area Number |
26462484
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Nagoya University |
Principal Investigator |
Kotani Tomomi 名古屋大学, 医学系研究科, 講師 (70359751)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 炎症 / 酸化ストレス / IL-6 / 神経障害 / LPS / 分子状水素 / ET-1 |
Outline of Final Research Achievements |
In mouse model of fetal brain damage caused by maternal inflammation, the effect of prenatal administration of molecular hydrogen was examined. In this research, maternal inflammation raised overproduction of pro-inflammatory cytokines and the induction of oxidative stress in fetal brain, followed by increased number of apoptotic cells. In addition, excessive activated microglia is involved in this inflammation and oxidative stress induced brain damage. Molecular hydrogen repressed microglia, which is suggested to play a protective role against inflammation and oxidative stress induced brain damage.In addition, maternal administration of molecular hydrogen reduced the inflammation at the maternal-fetal interface, which is also related with the protective role against fetal brain damage.
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Free Research Field |
産婦人科学
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