2016 Fiscal Year Final Research Report
Central control of GnRH neuron
| Project/Area Number |
26462491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | GnRH / Kisspeptin / Hypothalamus |
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| Outline of Final Research Achievements |
Hypothalamic secretion of gonadotropin-releasing hormone (GnRH) has been established as a principle pathway for initiating and integrating female reproductive function. GnRH stimulates the release of two gonadotropins which eventually stimulate the synthesis of sex steroids in association with follicular growth and ovulation. After the discovery of the indispensable role of kisspeptin in the development of human reproductive functions, our understanding of the neuroendocrine regulation of the HPG axis was revolutionized, and it is now recognized that kisspeptin acts upstream of GnRH and is responsible for sex steroid feedback mechanisms. Nevertheless, the detailed mechanisms underlying the regulation of homogeneous populations of GnRH neurons are still largely unknown.We studied how GnRH-producing cells respond to hypothalamic factors and how they are involved in GnRH synthesis.
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| Free Research Field |
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