Adverse pregnancy outcome

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462507
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NEKI REIKO 国立研究開発法人国立循環器病研究センター, 病院, 室長 (90600594)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 不育症 / 先天性血栓性素因 / 妊娠合併症 / 妊娠高血圧症候群 / 妊娠高血圧腎症 / 補体因子 / 遺伝子異常

Outline of Final Research Achievements

The present study was conducted to reveal the frequency of the low-frequency thrombophilic protein S K196E mutation, as well as the frequency of very rare nonsynonymous mutations in protein S, protein C, and antithrombin genes, in patients with adverse pregnancy outcomes. Although the low-frequency protein S K196E mutation can increase the risk for venous thromboembolism, it did not increase the risk for adverse pregnancy outcomes even in Japanese.
To reveal the possible genetic link between preeclampsia and complement system, genetic analysis was conducted including 6 major complement genes. Six patients were enrolled and 4 patients were so far analyzed. There were no genetic variations associated with preeclampsia.

Free Research Field

周産期医学