2016 Fiscal Year Final Research Report
Integrated analysis of cervical cancer using chemogenomics and radioimaging
| Project/Area Number |
26462521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 子宮頸癌 / 化学療法 / マイクロアレイ |
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| Outline of Final Research Achievements |
To investigate the efficacy of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy for cervical cancer, translational research in vitro, in silica, and in vivo was conducted.
Microarray analysis revealed that the glutathione metabolic pathway was significantly associated with NAC-resistance, while serum genotyping revealed that UGT1A1 polymorphisms were associated favor-response. And activation of the TGF-β pathway via the interaction between cacner cells and surrounding cancer-associated fibroblasts facilitated tumor invasion, and increased pSMAD3 expression was a hallmark of metastasis. As the clinical efficacy of individualized therapy for locally advanced cervical cancer, less toxicity of NAC and modified surgery was retrospectively exhibited as a single institute study and a multi-institutional study, retrospectively.
Furthermore, radiomics exhibited magnetic resonance imaging was also a useful predictor of the tumor activity as well as a diagnostic tool.
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| Free Research Field |
産婦人科
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