2016 Fiscal Year Final Research Report
Molucular basis on carcinogenesis in gastric-type adenocarcinoma of the uterine cervix
| Project/Area Number |
26462524
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
SUDO TAMOTSU 神戸大学, 医学研究科, 医学研究員 (50397824)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 子宮頚部胃型腺癌 / ハイリスクHPV |
|---|
| Outline of Final Research Achievements |
(1)The characteristic cytologic findings of gastric-type adenocarcinoma of the uterine cervix(GAS) include monolayered and honeycomb sheets, vacuolar and/or foamy cytoplasm, intracytoplasmic neutrophil entrapment, and vesicular nuclei with prominent nucleoli. (2) High-risk HPVs were detected 10 of 46 cases of GAS (21%).(3)Mutations of PDGFRA( platelet-derived growth factor receptor alpha), APC(Adenomatous polyposis coli) and FLT3(FMS-like tyrosine kinase 3) were identified in 3 cases of GAS via Next Generation Sequencing (NGS).
|
| Free Research Field |
医歯薬学
|
