Role of chemokine systems and its relation to immunotolerance and angiogenesis in ovarian cancer progression

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462535
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Wakayama Medical University
• Principal Investigator: INO Kazuhiko 和歌山県立医科大学, 医学部, 教授 (60303640)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 婦人科腫瘍 / 卵巣癌 / ケモカイン / 血管新生 / 免疫寛容 / ノックアウトマウス

Outline of Final Research Achievements

Interaction between tumor and stromal cells through chemokine systems was essential for cancer progression. The purpose of this study is to explore the pathophysiological roles of CX3CL1-CX3CR1 and CCR5 systems in ovarian cancer progression. A murine ovarian cancer cell line ID8 was used. When ID8 cells were inoculated to WT and Cx3cr1-/- mice, Cx3cr1-/- mice survived significantly longer than WT ones, and the tumor number in the abdominal cavity was significantly reduced in Cx3cr1-/- mice. Similarly, when ID8 cells were inoculated to WT and Ccr5-/- mice, tumor dissemination in abdominal cavity and tumor angiogenesis were significantly suppressed in Ccr5-/-mice compared with WT mice. These findings suggest that these chemokine networks are essential for ovarian cancer progression, and that CX3CR1 and CCR5 systems might be candidate molecules for a novel targeted therapy of ovarian cancer.

Free Research Field

婦人科腫瘍学