2017 Fiscal Year Final Research Report
Search for drug resistance genes in ovarian cancer cells by new exhaustive genome screening method
| Project/Area Number |
26462537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
NOMURA HIROYUKI 慶應義塾大学, 医学部(信濃町), 助教 (50327590)
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| Research Collaborator |
KATAOKA Fumio
YAMAGAMI Wataru
CHIYODA Tatsuyuki
IGUCHI Yoko
HASHIMOTO Shiho
IWASA Naomi
NAKADAIRA Naoki
YOSHIHAMA Tomoko
NANKI Yoshiko
DOZEN Ai
SAOTOME Keiko
TANAKA Hideo
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 薬剤反応性 / 抗がん剤 / 卵巣癌 |
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| Outline of Final Research Achievements |
We aimed to identify drug resistance gene in ovarian cancer cell line using a novel wide gene screening method. We also examined the association between single nucleotide polymorphisms (SNPs) and genetic markers involved in stress response or drug resistance.
We were able to obtain drug-resistant colonies of ovarian cancer cell lines for screening drug resistant genes and obtain basic data, and to verify experimental condition setting. However, it was difficult to stably establish colonies in cell lines derived from some histological types, leaving a problem in applying this method widely. In addition, a correlation between SNPs on taxane metabolism-related genes and sensitivity to cytotoxic drugs was suggested.
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| Free Research Field |
産婦人科学
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