Reconstitution of gynecological cancer microenvirnment

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462542
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Murata Takuya 川崎医科大学, 医学部, 講師 (20714207)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がんの微小環境 / 癌関連線維芽細胞 / 子宮頸癌 / 細胞間相互作用

Outline of Final Research Achievements

Reconstitution of cancer microenvirnment in vitro and/or in vivo is still difficult to achieve. If complete reconstitution of cancer microenvirnment be possible, it will be the break through to new cancer treatment, making cancer drug screening easier and find new biological mechanism that can be a new treatment target. In the course of the study, we found that cancer-associated fibroblast can make ME180, cervial caner cell line, metastasize to lymph nodes at the rate of as high as 40%, by co-transplanting these two kind of cells in nude mouse subcutaneously, that never occured if single kind of cancer cell was transplanted. By further studying this phenomenon, it may be possible to reconstitute cervical cancer microenvirnment in nude mouse subcutaneous completely.

Free Research Field

がんの微小環境解析