2016 Fiscal Year Final Research Report
Roles of IGF1 signaling in age-related hearing impairment
| Project/Area Number |
26462557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 内耳 / 加齢性難聴 / インスリン様細胞増殖因子１ / 感音難聴 |
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| Outline of Final Research Achievements |
In the present study, we investigated roles of IGF-1 signaling in the onset of age-related hearing impairment aiming drug development for age-related hearing impairment. We analyzed ages of the onset of age-related hearing impairment in three mouse strains, which have different mechanisms and timing for age-related hearing impairment by means of physiological and morphological assessments. Thereafter, changes in mRNA levels of IGF-1 signaling associated molecules just before the onset of age-related hearing impairment were examined using q-PCR. As results, we determined ages when age-related hearing impairment appear in three strains, and identified changing expression patterns of molecules associated with IGF-1 signaling at the onset of age-related hearing impairment in C57BL6 mice.
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| Free Research Field |
耳鼻咽喉科学
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