2016 Fiscal Year Final Research Report
Intravenous administration of neuronal stem cells alleviates hearing loss after transient cochlear ischemia
| Project/Area Number |
26462560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 内耳虚血 / 内有毛細胞 / 神経幹細胞 / 再生治療 / 活性酸素 / 神経栄養因子 |
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| Outline of Final Research Achievements |
Intravenous administration of neuronal stem cells (NSCs) is regarded to be a potential approach for promoting repair of damaged organs. Here, we investigated the influence of intravenous administration of NSCs on progressive hair cell degeneration after transient cochlear ischemia in gerbils. Transient cochlear ischemia was produced by the extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Intravenous administration of NSC prevented ischemia-induced hair cell degeneration and ameliorated hearing impairment. We also showed that the NOx level in the organ of Corti was suppressed after cochlear ischemia by treatment with NSC. Thus, we propose the intravenous administration of NSCs as a potential new therapeutic strategy for hearing loss by suppressing the production of NOx in the organ of Corti after ischemia.
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| Free Research Field |
医歯薬学
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