2017 Fiscal Year Final Research Report
Clinical study using Autologous human nasal epithelial cell sheet for transplantation after middle ear surgery.
| Project/Area Number |
26462569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
和田 弘太 東邦大学, 医学部, 教授 (20307482)
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| Research Collaborator |
Yamamoto Kazuhisa
Morino Tunetaro
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 再生医療 / 鼓室形成術 / 真珠腫性中耳炎 / 癒着性中耳炎 / 鼻粘膜上皮細胞シート |
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| Outline of Final Research Achievements |
We developed a novel treatment method combining tympanoplasty and autologous nasal mucosal epithelial cell sheet transplantation for postoperative regeneration of the middle ear mucosa. In clinical research, we endoscopically removed an approximately 10×10mm piece of nasal mucosal tissue. Tissue-engineered autologous nasal mucosal epithelial cell sheets were fabricated by culturing the harvested cells in an aseptic environment in a good manufacturing practice-compliant cell processing facility. The cultivated cell sheets were transplanted, during tympanoplasty, onto the exposed bony surface of the attic of the tympanic and mastoid cavities where the mucosa had been lost. We performed this procedure on five patients with middle ear cholesteatoma and one patient with adhesive otitis media. All patients showed favorable postoperative course with no adverse events or complications and the patients’ hearing ability post-transplantation remained good.
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| Free Research Field |
耳鼻咽喉科
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