2016 Fiscal Year Final Research Report
Efficacy of clarithromycin against avian influenza A virus
| Project/Area Number |
26462583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | インフルエンザウイルス / マクロライド / クラリスロマイシン / カニクイザル |
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| Outline of Final Research Achievements |
To examine the efficacy of Macrolide antibiotics, including clarithromycin (CAM), a 14-membered ring macrolide against avian influenza virus (H5N1, H7N9) infection, we examined the effects of oral CAM administration in H5N1- or H7N9-infected cynomolgus macaque monkeys.
H5N1 infection caused a severe infection in monkeys, while H7N9 infection resulted in a mild disease. CAM significantly suppressed H5N1-induced severe infection evaluated by the lower clinical score and by the lower body temperature at 5 days after the infection. CAM also significantly inhibited the virus titers in tracheal swab and the production of inflammatory cytokines in lungs in both H5N1- and H7N9- infected monkeys. These findings suggest that orally administered CAM attenuates the severity of avian influenza A virus (H5N1, H7N9) infection in monkeys by inhibiting the infection and reproduction of viruses and by suppressing the cytokines responses of infected lung.
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| Free Research Field |
感染免疫
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