We investigate an etiology of the lower respiratory tract disease by intractable factor in eosinophilic chronic rhinosinusitis.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Toho University
• Principal Investigator: WADA Kota 東邦大学, 医学部, 教授 (20307482)
• Co-Investigator(Renkei-kenkyūsha): YOSHIKAWA Mamoru 東邦大学, 医学部, 教授 (50277092) ; KONDO Motonari 東邦大学, 医学部, 教授 (20594344)
• Research Collaborator: INOUE Akiko
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 好酸球性副鼻腔炎 / 上皮細胞 / 線維芽細胞 / IL-33 / TSLP / ウィルス感染

Outline of Final Research Achievements

We stimulated it using Poly I; C which was a ligand of TLR3 which became false of the viral infection.　IL -33 was not detected, and there is no significant difference in TSLP. However, TSLP is tended to high in ECRS group.
Immunostaining, the examination of mRNA are going to be carried out in future, too.　Particularly, we want to make an effort because it is thought that IL -33 accumulates in cells so that we think that the immunostaining is important, and further results are obtained.

Free Research Field

耳鼻咽喉科学