Study of topical antibody production in sinus mucosa of refractory rhinosinusitis cases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nippon Medical School
• Principal Investigator: Matsune Shoji 日本医科大学, 医学部, 教授 (00253899)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 難治性副鼻腔炎 / 篩骨洞粘膜 / 抗原特異的IgE / 総IgE / 真菌 / 菌体エンテロトキシン / 濾胞樹状細胞

Outline of Final Research Achievements

Intractable chronic rhinosinusitis often complicated with multiple polyposis and asthma is named eosinophilic rhinosinusitis. Our operation cases were classified into two groups such as eosinophilic chronic rhinosinusitis (ECRS) and non-eosinophilic one (nonECRS) and compared topical total and specific IgE levels in ethmoid mucosa between these two groups. In ECRS, the topical total and specific IgE to cedar pollen and candida were significantly increased than in nonECRS. The topical specific IgE to enterotoxin A, B (Staphylococcus aureus) and aspergillus were also increased in ECRS than in nonECRS, which difference was not significant. The distribution of IgE-positive mononuclear cells in ethmoid mucosa was found to support the results of IgE-level analysis, histologically. Follicular dendritic cells were occasionally identified to form inflammatory lymphoid follicles in ethmoid mucosa and supposed to involved in topically producing total and/or specific IgE.

Free Research Field

Otolaryngology