Establishment of experimental and clinical evidences for tonsillectomy as a treatment of tonsillar focal diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462593
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Takahara mIKI 旭川医科大学, 医学部, 講師 (50322904)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 扁桃病巣疾患 / IgA腎症 / 掌蹠膿疱症 / 胸肋鎖骨過形成症 / APRIL / CXCR3 / CX3CR1

Outline of Final Research Achievements

IgA nephropathy (IgAN), pustulosis palmaris et plantaris（PPP）, and sternocostoclavicular hyperostosis (SCCH) are famous for typical tonsillar focal diseases, and tonsillectomy has been reported to be effective for improvement of the diseases. Unfortunately, this fact was not widely known. We try to establish experimental and clinical evidences for tonsillectomy as a treatment of tonsillar focal diseases in order to enlighten other doctors on the effectiveness and clarify a factor which predict the effectiveness.
In this serious of studies, we showed the effectiveness of tonsillectomy for PPP skin lesions by objective evaluation. Moreover, we found that APRIL (a proliferation-inducing ligand) was involved in hyper-production of IgA from the tonsils of IgAN patients, and that chemokine receptor CXCR3 and CX3CR1 on tonsillar T-cells was related to homing of T-cells to the lesions of glomerulus. We will continue to study in order to show more evidences.

Free Research Field

扁桃病巣疾患