2016 Fiscal Year Final Research Report
Investigation into the predictor of cetuximab effect based on microRNA in head and neck squamous cell carcinoma
| Project/Area Number |
26462596
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 頭頸部扁平上皮癌 / マイクロRNA / セツキシマブ / 治療効果予測因子 |
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| Outline of Final Research Achievements |
In this study, we newly constructed the RNA sequencing based miRNA expression signature by using clinical specimens. Based on the expression signature, we have identified several antitumor miRNAs and these miRNAs regulated oncogenic targets in head and neck squamous cell carcinoma (HNSCC) cells. miR-1 and miR-206 were significantly reduced HNSCC tissues and ectopic expression of these miRNAs inhibited HNSCC cancer cell aggressiveness. We found that two growth factor receptors, epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-MET), were directly regulated by both miR-1 and miR-206 in HNSCC cells. Moreover, several reports showed that EGFR inhibitors induced c-MET signal activation, suggesting a possible mechanism of acquired resistance to EGFR inhibitors. The identification of targets modulated by tumor-suppressive miR-1 and miR-206 may lead to a better understanding of molecular pathogenesis of HNSCC.
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| Free Research Field |
頭頸部がん
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