2016 Fiscal Year Final Research Report
Demethyalte analusis by usin tet-assist bisulfite method in HNSCC.
| Project/Area Number |
26462600
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 頭頸部癌 / DNAメチル化酵素 / 脱メチル化酵素 |
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| Outline of Final Research Achievements |
This study examined DNA methylation enzymes (DNMT3A, DNMT3B) and DNA demethylation enzymes (TET1, TET2, TET3) expression and profiles of head and neck cancer (HNSCC) patients. This study suggests that DNMT3A, DNMT3B, TET1, TET2, TET3 are a likely mechanism of X gene inactivation, supporting the hypothesis that the X gene may play a role in the tumorigenesis of HNSCC and may serve as an important biomarker.
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| Free Research Field |
頭頸部癌
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